On their way back home during the spring break, Darry and Patricia Jenner witness a mysterious person dumping something down a tunnel. Deciding to discover what was dumped down there, Darry discovers a huge disturbing hideout full of modified bodies. Darry and Patricia set off to get help, unaware that the individual is now aware of who has been down the tunnel. Darry and Patricia soon realizes that their pursuer is not just a mysterious person, but something even more horrifying, who has more in store than they could possibly imagine.
Stranded on a lonely road, a schoolbus full of high school basketball players, their coaches, and cheerleaders must defend themselves from the Creeper - a flesh-eating ancient beast that resurfaces on the earth every 23 years to feed. Meanwhile, a farmer and his son set out on a personal mission to hunt the Creeper down.